Correspondence from The New England Journal of Medicine — Cellulitis. To the Editor: In their article on the Prophylactic Antibiotics for the Treatment of Cellulitis at Home I (PATCH I) trial, Thomas et al. (May 2 issue)1 report that the. In a recent retrospective study of patients who were hospitalized with presumed cellulitis, dermatologists concluded that roughly 30% of.

Author: Zulkishicage Kazizahn
Country: Tajikistan
Language: English (Spanish)
Genre: Health and Food
Published (Last): 12 November 2009
Pages: 231
PDF File Size: 1.20 Mb
ePub File Size: 15.80 Mb
ISBN: 463-3-92439-962-2
Downloads: 19203
Price: Free* [*Free Regsitration Required]
Uploader: Kagagrel

N Engl J Med.

Leg Ulcers and recurrent cellulitis

Prophalactic antibiotics for vellulitis prevention of cellulitis erysipelas of the leg: Statins can interact with some antibiotics and increase the risk of rhabdomyolysis. Comment in N Engl J Med. The median time to a first recurrence of cellulitis was days in the penicillin group and days in the placebo group.

Amiodarone and drugs which prolong the QT interval can interact with many antibiotics. Leg Ulcers and recurrent cellulitis. Participants were followed for up to 3 years. Are they suitable for compression?


Doses are oral and for adults unless otherwise stated. Is it chronic changes of venous stasis and chronic ulceration? Skip to main content. Clelulitis conducted a double-blind, randomized, controlled trial involving patients with two or more episodes of cellulitis of the leg who were recruited in 28 hospitals in the United Kingdom and Ireland.

Leg Ulcers and recurrent cellulitis –

Refer for specialist opinion if severe infection Is it cellulitis? Colonisation is likely in leg ulcers. Please refer to our Drug Interactions Table for further information. Bilateral cellulitis is uncommon. We compared prophylactic low-dose penicillin with placebo for the prevention of recurrent cellulitis.

Treat tinea pedis or candida infection with topical terbenifine or miconazole respectively. Because the risk of recurrence was not constant over the 3-year period, the primary hypothesis was tested during prophylaxis only. Many antibiotics increase the risk of bleeding with anticoagulants.

Penicillin to prevent recurrent leg cellulitis.

Review antibiotics after culture results. Baseline characteristics were similar in the two groups. Penecillin to prevent leg cellulitis NEJM ; Overall, participants in the penicillin group had fewer repeat episodes than those in the placebo group vs.


Cellulitis of the leg is a common bacterial infection of the skin and underlying tissue. In patients with recurrent cellulitis of the leg, penicillin was effective in preventing subsequent attacks during prophylaxis, cellulifis the protective effect diminished progressively once drug therapy was stopped.

The primary outcome was the time to a first recurrence. Randomization was performed according to a computer-generated code, and study medications penicillin [ mg twice a day] or placebo for 12 months were dispensed by a central pharmacy. Antibiotics do not improve healing unless active infection. Comments from Expert Advisory Committee Antibiotics do not improve healing unless active infection.

A total of patients were recruited.