Crystallization of Biological Macromolecules, by Alexander McPherson. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory. Crystals of macromolecules have become keystones of molecular biology, bridging Chapter 3: The Purification and Characterization of Biological Macromolecules ~xray/Books/ Results 1 – 19 of 19 Crystallization of Biological Macromolecules by Alexander McPherson and a great selection of related books, art and collectibles available.

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Initial crystals are frequently microcrystals or clusters, and often have unfavorable morphologies or yield poor diffraction intensities.

Crystallization of Biological Macromolecules

It is therefore generally necessary to improve upon these initial conditions in order to obtain better crystals crystallizatoon sufficient quality for X-ray data collection. About this book This extensively illustrated book provides a biochemical context in which crystal growth can be pursued and instructs readers in practical aspects of the technology, laying out effective strategies for success. The improvement process is referred to as optimization, and it entails sequential, incremental changes in the chemical parameters that influence crystallization, such as pH, ionic strength and precipitant concentration, as well as physical parameters such as temperature, sample volume and overall methodology.

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Conservation Land Management CLM is a quarterly magazine that is widely regarded as essential reading for all who are involved in land management for nature conservation, across the British Isles. Crstallization extensively illustrated book provides a biochemical context in which crystal growth can be pursued and instructs readers in practical aspects of the technology, laying out effective strategies for success. Keep up-to-date with NHBS products, news and offers.


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Crystallization of biological macromolecules

It also includes the application of some unique procedures and approaches, and the addition of novel components such as detergents, ligands or other small molecules that may enhance nucleation or crystal development. Praise of Chromosome Folly.

For the successful X-ray structure determination of macromolecules, it is first necessary to identify, usually by matrix screening, mcpherso that yield some sort of crystals. Salamanders in Regeneration Research. Molecular Cloning 3-Volume Set.

Benton Richard Fortey View All. The quality of an X-ray structure determination is directly correlated with the size and the perfection of the crystalline samples; thus, refinement of conditions should always be a primary component of crystal growth. Click to have a closer look. CLM includes long-form articles, macromokecules listings, publication reviews, new product information and updates, reports of conferences and letters.

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Crystallization of Biological Macromolecules – Alexander McPherson – Google Books

Cold Spring Harbor Laboratory Press. Stress Biology mcpberson Cyanobacteria. Here, an attempt is made to provide guidance on how optimization might best be applied to crystal-growth problems, and what parameters and factors might most profitably be explored to accelerate and achieve success.


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Optimization of crystallization conditions for biological macromolecules.

Molecules that Changed the World. Purifying and Culturing Neural Cells. Even when the initial samples are suitable, often marginally, refinement of conditions is recommended in order to obtain the highest quality crystals that can be grown. Published six times a year, Crywtallization Wildlife bridges the gap between popular writing and scientific literature through a combination of long-form articles, regular columns and reports, book reviews and letters.

Contents The history and character of macromolecular crystals; principles of macromolecular structure and the applications of x-ray crystallography; the purification and characterization of biological macromolecules; some physical and maceomolecules principles; macromlecules procedures for macromolecular crystallization; important considerations in macromolecular crystallization; strategies and special approaches in growing crystals; impurities, defects, and crystal quality; the mechanisms and kinetics of macromolecular crystal growth; crystal growth in unique environments.

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