ELIGARD PACKAGE INSERT PDF

ELIGARD (leuprolide acetate) is indicated for the palliative due to incorrect reconstitution or administration of the product (see Monitoring and Laboratory .. Gently insert the long, white replacement plunger rod into the gray. PACKAGE LEAFLET: INFORMATION FOR THE USER. ELIGARD 45 mg powder and solvent for solution for injection. Leuprorelin acetate. Read all of this leaflet. Eligard® is a sterile polymeric matrix formulation of leuprorelin acetate for subcutaneous package insert for constitution and administration procedures.

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In addition, there are postmarketing reports of torsade de pointes. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with leuprolide include fingolimod. Glasdegib therapy may result in QT prolongation and ventricular arrhythmias including ventricular fibrillation and ventricular tachycardia.

Major Chloroquine administration is associated with an increased risk of QT prolongation and torsades de pointes TdP. Release the diluent by slowing pushing the plunger for 6—8 seconds, until the first stopper is at the blue line in the middle of the barrel.

Maximum dosage must be individualized and is dependent on formulation, indication, and patient response.

Major The administration of artemether is associated with prolongation of the QT interval. Case reports suggest standard monthly injections eligafd 1. Such therapy does not compromise the efficacy of leuprolide in relieving endometriosis symptoms and may also reduce vasomotor symptoms and vaginal dryness associated with hypoestrogenism. If possible, avoid coadministration of amiodarone and drugs known to prolong the QT interval. Lithium has been associated with QT prolongation.

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Increase dose if needed to the next available higher dose e. In clinical trials, patients receiving this dosage eligarr from ECG monitoring is recommended during use. Leuprolide should be used with caution in patients with osteoporosis. Antipsychotic-induced hyperprolactinemia results in down-regulatation of the number of pituitary GnRH receptors and may interfere with the response to any of the gonadotropin-releasing hormone GnRH analogs e.

Rare case reports of QT prolongation have also been described when tamoxifen is used at lower doses. Local disease improved or remained stable in all patients at weeks 16 and Take care to verify the correct product and intent of use prior to administration.

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Eligard (leuprolide acetate) dose, indications, adverse effects, interactions from

GnRH analog therapy increases the risk of reduced bone mineral density in men as well as women, and may have particular relevance for the geriatric population. Insert the needle IM at a 90 degree angle and look for blood. There have been case reports of QT prolongation and TdP with the use of azithromycin in postmarketing reports.

The concomitant use of amiodarone and other drugs known to prolong the QT interval should only be done after careful assessment of risks versus benefits.

Drugs with a possible risk for QT prolongation that should be used cautiously and with close monitoring with citalopram include leuprolide. Asenapine might also decrease the clinical response to leuprolide.

Due to different release characteristics, Monthly, Three-Month, Four-Month, and Six-Month depot formulations are not equivalent at multiple or fractional doses; apparent equivalent doses from different formulations should not elibard given. Major Eligaed coadministration of encorafenib and leuprolide due to QT prolongation.

If these drugs are administered together, obtain an electrocardiogram and electrolyte concentrations before and periodically during treatment. Intramuscular dosage injection suspension, Lupron Depot-Ped 3-month.

If these drugs are used together, consider electrocardiogram monitoring. At this time, there are no known comparable studies evaluating the risk of diabetes in women or children taking GnRH agonists for other indications.

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Leuprolide therapy interrupts menstruation; women who continue to cycle or who experience breakthrough bleeding while receiving leuprolide should notify their physician. Major Concomitant use of ziprasidone and leuprolide should be avoided due to the potential for additive QT prolongation. QT prolongation should be expected with the administration of arsenic trioxide. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously with leuprolide include beta-agonists.

At this time, there are no known comparable studies evaluating the risk of cardiovascular events in women or children taking GnRH agonists for other indications. Because of the potential for TdP, use of thioridazine with leuprolide is contraindicated. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with leuprolide include telavancin. Insert the needle at a 90 degree angle into the gluteal area, anterior thigh, or shoulder.

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Due to the similarity in packaging, dose strengths, and routes of administration for some leuprolide products, always verify the dosage form, product name, intent of use, population of use and other clinically distinguishing factors prior to administration in order to avoid medication errors.

Severe Halofantrine is considered to have a well-established risk for QT prolongation and torsades de pointes TdP.

Because of the adverse reaction profile e. Major It is not common for these two agents to be used together at the same time, due to duplicate effects on hormone regulation. Use leuprolide with caution in patients with a preexisting seizure disorder. For the preoperative treatment of anemia due to uterine leiomyomata fibroids in combination with iron supplementation when iron therapy alone fails to correct the anemia. During postmarketing experience, emotional lability, such as crying, irritability, impatience, anger, and aggression were reported.

Major Androgen deprivation therapy e. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with chloroquine include leuprolide. Because the condition is reversible if the drug is discontinued, therapy must be continuous. Discard any suspension not used within 2 hours of reconstitution because it does not contain preservatives.

Major Androgen-deprivation therapy e. If concomitant use is unavoidable, closely monitor ECGs for QT prolongation and monitor electrolytes; correct hypokalemia or hypomagnesemia prior to administration of toremifene. The risk of myocardial infarction, sudden cardiac death, and stroke appears low but needs to be evaluated carefully along with cardiovascular risk factors like cardiac disease, tobacco smoking, hypertension, hypercholesterolemia, and obesity.

Torsade de pointes TdP and complete atrioventricular block have been reported. In addition, drugs that cause hyperprolactinemia, such as tetrabenazine, should not be administered concomitantly with gonadotropin-releasing hormone GnRH analogs leuprolide since hyperprolactinemia down regulates the number of pituitary GnRH receptors.