Phenytoin Injection prescription and dosage sizes information for physicians and healthcare professionals. Pharmacology, adverse reactions, warnings and side. Page 1. Page 4. Malta ADR Reporting website: adrportal 5. How to store Epanutin RMP The storage of Epanutin RMP will not be . Epanutin Injection is used for Seizure, Migraine, Cardiac arrhythmias and other conditions. Epanutin Injection may also be used for purposes not listed in this.

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The amount and concentration of fosphenytoin is always expressed in terms of mg PE. In this case, alternative therapy should be an antiepileptic epanuhin not belonging to the hydantoin chemical class.

Pro-Epanutin should not be used in women of childbearing potential unless other antiepileptic drugs are ineffective or not tolerated and when possible, the woman is made aware of the risk of potential harm to the foetus and the importance of planning pregnancy. Storage of Epanutin Injection Store medicines at room temperature, away from heat and direct light. Pro-Epanutin may cause foetal harm when administered to a pregnant woman.

The serum level achieved by a given dose is therefore also subject to wide variation.

Epanutin Ready Mixed Parenteral

Possible side effects 5. Each pack contains 10 ampoules. Acute hepatic failure, hepatitis toxic, liver injury.

Respiratory, thoracic and mediastinal disorders. John’s wort Hypericum perforatum. Volume mL to draw up. Other common manifestations include arthralgias, jaundice, hepatomegaly, leucocytosis, and eosinophilia. Check with your doctor or pharmacist if you are on long-term antiepileptic medication, have a history of osteoporosis, or take steroids. In all cases of lymphadenopathy, long term follow-up observations are indicated and every effort should be made to achieve epanutinn control using alternative antiepileptic drugs.


See Table 8 for infusion times. Epanutin Injection Side-effects The following is a list of possible side-effects that may occur from all constituting ingredients of Epanutin Injection.

See Table 10 for infusion times. Phenytoin is a potent inducer of hepatic drug-metabolizing enzymes and may reduce the levels of drugs metabolized by these enzymes. For this reason, plasma phenytoin concentrations may increase when IM or IV Pro-Epanutin is substituted for oral phenytoin sodium therapy.

Table 4 displays dosing information for seizure treatment or prophylaxis maintenance dose in adults. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at www. Because of the risk of local toxicity, intravenous phenytoin should be injected slowly directly into a large vein through a large-gauge needle or intravenous catheter.

There iniection a higher incidence of this in black patients.

Some of these events have been fatal e;anutin life threatening. The pharmacist or nurse will throw away any medicine you no longer use. Date of revision of the text. Elimination The parameters controlling elimination are also subject to wide interpatient variation. In these patients with acute hepatotoxicity, phenytoin should be immediately discontinued and injectioon re-administered. Patients with impaired liver function, elderly patients, or those who are gravely ill may show early signs of toxicity.

Cardiac adverse events have also been reported in adults and children without underlying cardiac disease or comorbidities and at recommended doses and infusion rates. To bookmark a medicine you must sign up and log in. It is not possible epanuton set forth a universally applicable dosage schedule.

Epanutin RMP with food, drink and alcohol Drinking a lot of alcohol can also affect the concentration of phenytoin in your blood. Please refer to Tables for examples of dosing, dilution, and infusion time calculations Population Indication Dosing Table Adults Status epilepticus Loading dose Table 1 Status epilepticus Maintenance dose Table 2 Seizure treatment or prophylaxis Loading dose Table 3 Seizure treatment or eapnutin Maintenance inuection Table 4 Temporary substitution for oral phenytoin Table 5 Children aged 5 years and older Status epilepticus Loading dose Table 6 Status epilepticus Maintenance dose Table 7 Seizure treatment or prophylaxis Loading dose Table 8 Seizure treatment or prophylaxis Maintenance dose Table 9 Temporary substitution for oral phenytoin Table These side-effects are possible, but do not always occur.


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N03AB05 Eppanutin is a prodrug of phenytoin and accordingly, its anticonvulsant effects are attributable to phenytoin. The modulation of sodium channels may be a primary anticonvulsant mechanism because this property is shared with several other anticonvulsants in addition to phenytoin. If you suddenly stop taking this medicine you may have a seizure. Severe complications are most commonly encountered in older people or gravely ill patients. The dose of anticonvulsant may need adjusting.


Soft tissue irritation and inflammation has occurred at the site of injection with and without extravasation of intravenous phenytoin. Haematopoietic complications, some fatal, have occasionally been reported in association with administration of phenytoin. Renal and urinary disorders Not Known Tubulointerstitial nephritis General disorders and administration site conditions Not Known Local irritation, inflammation, tenderness, necrosis, oedema iinjection skin exfoliation have been reported with or without extravasation of intravenous phenytoin.