This review presents an analysis of the current data on the structural and functional organization and biological significance of epithelial cell rests of Malassez. Definition: The epithelial cell rests of Malasse are discrete clusters of residual cells from Hertwig’s epithelial root sheath (HERS) that didn’t. The authors performed a PubMed search on the term “epithelial rests” alone or in combination with “Malassez.” Relevant articles were categorized into primary.

Author: Vugul Bami
Country: Libya
Language: English (Spanish)
Genre: Technology
Published (Last): 5 November 2013
Pages: 67
PDF File Size: 4.74 Mb
ePub File Size: 3.7 Mb
ISBN: 788-6-76128-673-1
Downloads: 89352
Price: Free* [*Free Regsitration Required]
Uploader: Zugal

For a long time, the scientific literature has not even hypothesized a role for the epithelial rests of Malassez ERM. Epithelial cell rests of Malassez were first described by Augustin Serres in Epithelial cell rests of Malassez contain unique stem cell populations capable of undergoing epithelial-mesenchymal transition.

Skills gained at the workshop are now poised to bring advanced, pain reduced dental treatment to South African consumers.

Mechanisms of tooth eruption and orthodontic dpithelial movement.

Epithelial rests of Malassez: from latent cells to active participation in orthodontic movement

Alveolodental ankylosis is characterized by the absence of tooth elastin due to the loss of periodontal ligament cells associated with root resorption. Reviews on this topic are infrequent in the dental literature and the notable advances regarding the cytokine profile of the epithelial cell rests of Malassez and their autocrine and paracrine roles in the periodontal tissues make it opportune to review their physiological roles in maintaining periodontal health.

For more information on SciVision and Biolase technology, visit http: Expression and role of epidermal growth factor receptors during differentiation of cementoblasts, osteoblasts, and periodontal ligament fibroblasts in the rat. During the early inflammatory events that compose the induced movement process, the constriction of the microvasculature of the periodontal ligament results in focal areas of necrosis, with histological features of hyalinization.

Epidermal growth factor receptor regulates osteoclast differentiation and survival through cross-talking with RANK signaling. However, Ten Cate 21 stated that ERM had a role in the formation of dental cysts, because the remaining epithelial cells from ERM behave the same way as other epithelial cells when the local tissue is changed.

J Periodontol ; 79 5: ERM keep the bone away from the root surface through the release of mediators such as EGF, which induces osteoclasia. J Cell Sci Suppl ; 3: Periodontal Ligament Search for additional papers on this topic. Macrophage-colony stimulating factor M-CSF and several transcription factors are required for the final transformation of haematopoietic stem cells to osteoclasts.


Malassez 7 was the first to detail the histological characteristics of epithelial rests and their distribution in the periodontal epitheelial. These cell rests proliferate to form epithelial lining of various odontogenic cysts such as radicular cyst under the influence of various stimuli. The most important aspect of laser dentistry is having an adequately qualified dentist to use a laser on a patient, in a successful way.

Epithelial rests of Malassez: Interestingly, Serres 5 epiyhelial approached the occurrence of HERS degeneration in the same work that described the enamel organ debris, but did not relate these events with each other.

Ectomesenchymal cells also induce the differentiation of the insertion periodontium. The bone morphogenetic malasssez, especially BMP-2, as well as bone matrix proteins, act in regulating osteogenesis, with an initial rise in the dental follicle. This role is contrary to the events resulting from the induced orthodontic tooth movement.

The prevalence, distribution, and morphologic changes of the epithelial remnants in the molar region of the rat. Orthodontic movement, however, does not promote ERM necrosis, but, rather, just the reverse. Otherwise, more studies are necessary to clarify these functions and consequences in daily orthodontics practice. Unlike bone cells, cementoblasts do not have receptors for remodelling nalassez, requiring the beginning of a cascade of events that causes the pH to normalize.

Cited by Google Similars in Google. Meanwhile, recent findings are indicative of high functional activity of ERM which are both producers of and targets for various cytokines, growth factors, adhesive substances, their receptors and other biologically active molecules.

Epithelial cell rests of Malassez

From their potential in the context of maintaining periodontal insertion through the release of inflammatory mediator structures, proteins and growth factors, the ERM were epitgelial as key figures in maintaining homeostasis, assisting in the maintenance of space in the periodontal ligament, cementum repair and regeneration processes and collagen renewal. An ultrastructural evaluation of the relationship between epithelial rests of Malassez and orthodontic root resorption and repair in man.

The significance of epithelial rests of Malassez in the periodontal ligament. Hyalinization during orthodontic tooth movement a systematic review on tissue reactions. Gutknecht were of high calibre – his professionalism and 25 years of laser research knowledge reminded us that practicing with lasers drives practitioners to achieve dental results on a higher level.


Epithelial cell rests of Malassez – Wikipedia

South Epitheliall is the ideal market to focus on the use of dental lasers as it has dedicated, highly skilled and progressive dentists in good facilities. In this procedure, epithelial cells associated with ERM modify their distribution and express BMP-2, osteopontin and ameloblastin.

This page was last edited on 23 Marchat When properly executed, the orthodontic movement is able to stimulate the secretory power of these epitehlial, which prevents the recurrence of ankylosis.

In vitro characterization of the cytokine profile of the epithelial cell rests of Malassez. The actions of these mediators result in bone remodelling, which involves resorption or bone deposition on opposite side of the periodontal ligament. Damage to periodontal tissue is directly associated with orthodontic movement, where hyalinizing outbreaks have been recorded on the pressure side in the periodontal ligament, mainly during the first hours after the application of force.

Initially described by Serres, 5 these remaining cells of the periodontal ligament are portrayed as enamel organ debris. Damage to periodontal tissue is directly associated with orthodontic movement, where hyalinizing outbreaks have been recorded on the pressure side in the periodontal ligament, mainly during the first hours after the application of force.

The regeneration of periodontal tissue occurs through assistance in the renewal of cells that suffered some sort of damage. Reeve and Wentz 16 determined the frequency of epithelial rests in patients aged years, classifying different ERM types and locations on the periodontal ligament.

Services on Demand Article. Also in this section hyperplastic dental follicle epithelial root sheath epithelial cell rests of Malassez dental germ enamel pearl oculodentodigital dysplasia enamel dysplasia with hamartomatous atypical follicular hyperplasia dentine dysplasia dentinogenesis imperfecta hereditary dentine diseases. The rets, morphology, and distribution of epithelial rests in the human periodontal ligament. The actions of these mediators result in bone remodelling, which involves resorption or bone deposition on epitheloal side of the periodontal ligament.

Initially, its latent or quiescent role was associated only to the formation of cysts and periapical granulomas.