ergogenic aid for increase sports performance seems to have potential () L-Arginine as a Potential Ergogenic Aidin Healthy Subjects. L-arginine as a potential ergogenic aid in healthy subjects. Sports Medicine, 41(3 ), doi/ Bahra, M., Kapil, V. Dietary nitrates and L-Arginine have been increasingly recognized to play a promising Recently, nitric oxide (NO) has emerged as a promising ergogenic aid by .. factor for exercise tolerance in healthy subjects, suggesting the potential of.

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In order to better understand the magnitude of this heterogeneity, it is worth noting that 7 g of L-Arginine before each resistance exercise bout seems not subjectx influence strength performance, as well as muscle blood volume and oxygenation, while 10 g of L-Arginine seem to proportionate measurable benefits.

NO 3 -based supplements show the most promise. International Journal of Sports Medicine28 6 Indeed, this paradox refers to specific situations in which L-Arginine supplementation appears to stimulate NOS activity, even when endogenous levels are found in a physiological range [ 10 ].

L-Arginine as a potential ergogenic aid in healthy subjects.

There is also a lack of studies that observed elderly and female populations. L-arginine reduces exercise-induced increase in plasma lactate and ammonia. Some mechanistic studies have disclosed that NO 3 – may also reduce the ATP cost of muscle hhealthy production, as well as improve mitochondrial respiration efficiency [ 25 ]. Effects of creatine loading and prolonged creatine supplementation on body composition, fuel selection, sprint and endurance performance in humans.

Protein- and carbohydrate-induced augmentation of whole body creatine retention in humans. This paper will explore whether or not these common forms of NO supplementation work, through which mechanisms they might act, and under what conditions.

Nitric Oxide/Arginine: Is Cardiovascular Modulation Effects in Athletes Supplementation?

In addition to its role as a precursor for NO production and protein synthesis, in some instances exogenous arginine can act as potentia secretagogue, promoting growth hormone release via an inhibitition of somatostatin secretion 28 — Potential ergogenic effects of arginine.

Nevertheless, some studies report acute cardiovascular modulation, particularly associated with high doses of lotential 30 g maximumsuch as hypotension with compensatory tachycardia, reduced peripheral arterial resistance and increase in cardiac output [ 10 ].


Highly trained athletes have the lowest-percent increases post-ingestion and are not likely to gain any performance benefit from erbogenic additional NO 3. Studies also show that the optimal time to take NO 3 supplements is 2. No effect of creatine supplementation on human myofibrillar and sarcoplasmic protein synthesis after resistance exercise.

It has repeatedly been shown that the muscle concentration of total creatine can indeed be increased by oral creatine supplementation. In addition to this, NO inhibits leukocyte adhesion, platelet aggregation, superoxide generation, expression of vascular cell adhesion molecules and monocyte chemotactic peptides, smooth muscle proliferation and endothelin-1 a vasoconstrictor release [ 19 ]. In this case the reduction of the intracellular availability of EAAs would be expected to decrease the rate of muscle protein synthesis unpublished observation, Durham, W.

L-Arginine as a potential ergogenic aid in healthy subjects.

Dietary nitrates and L-Arginine have been increasingly recognized to play a promising role as sport dietary supplementation, getting more and more popular as ergogenic aids, namely, substances used with regard to performance enhancement. Journal of the International Society of Sports Nutrition4 16. Another possible speculation consists of an increased inhibition of cytochrome C oxidase by NO, which might be sensed by cells as mild hypoxia, with the consequent activation of signalling mechanisms that result in downregulation of adenine nucleotide translocase ANTa protein involved in mitochondrial proton conductance, and improved mitochondrial efficiency, enforced by the lack of increase in lactate concentration [ 1723 ].

After oral administration, L-Arginine is extensively metabolized by Arginases in the gut wall and liver, increasing blood flow due to the provision of nitric oxide, providing oxygen and nutrients [ 223538 ].

Of this, approximately one-third is free creatine, whereas two-thirds exist as phosphocreatine PCr. Creatine supplementation patterns haelthy perceived effects in select division I collegiate athletes.

During a 5 wk progressive strength training program, volunteers were given a placebo or supplement containing 1 g arginine and 1 g ornithine each day.

N -guanidino-acetate methyltransferase GAMT and the creatine transporter. Supplementation has also been shown to have neuroprotective effects in several animal models of neurological diseases, e.

Confirmation of this notion comes from an experiment performed in normal volunteers to determine the role of the elevation in the rate of muscle blood flow in the response of muscle protein synthesis to resistance exercise.


The increase in plasma nitrite after a dietary nitrate load is markedly attenuated by an antibacterial mouthwash. To make matters even more plotting, some authors argue that dietary nitrate supplementation not only enhances blood flow to contracting muscle, but may also increase muscle function during normal movement, which is consistent with the effects of nitrate on muscle efficiency being, at least, partially explained by extramitochondrial mechanisms [ 23 ]. L-Arginine supplementation, in combination with Glutamate and Aspartate, is known to be effective at reducing blood levels of ammonia, as well as blood lactate, during exercise [ 8 ].

Conversely, ingestion of all the NEAAs that were deleted in this experiment, including arginine, had no effect on muscle protein synthesis. Nevertheless, increasing plasmatic NO 2 – levels via dietary supplementation with NO 3 – may represent a practical and cost-effective intervention to restore NO homeostasis and improve exercise tolerance in these populations [ 25 ]. Nitrate-based supplements taken 2. A reexamination of the effects of creatine on muscle protein synthesis in tissue culture.

Scientific opinion of the panel on contaminants in the food chain. A nutritional supplement that enhances exercise capacity and is consumed before, during or after training, is known to have an ergogenic effect [ 24 ]. Due to health and ethical concerns, human supplementation with pharmaceutical NO 3 was not allowed in the United Kingdom Jones et al. Arginine supplementation has been shown to improve NOdependent endothelial relaxation in patients with major cardiovascular risk factors hypercholesterolemia, smoking, hypertension, diabetes, obesity, insulin resistance, aging and many ordinary cardiovascular disorders [ 12 ].

NO, a labile and short half-life molecule present in many biological fluidsis one of the most widespread signaling molecules, participating in virtually every cellular and organic function in body [ 1213 ].